Blar i NTNU Open på forfatter "Nilsson, K. Peter R."
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ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
Caesar, Ina; Nilsson, K. Peter R.; Hammarström, Per; Lindgren, Olof Mikael; Prokop, Stefan; Heppner, Frank L.; Schmeidler, James; Haroutunian, Vahram; Holtzman, David M.; Hof, Patrick R.; Gandy, Sam (Peer reviewed; Journal article, 2023)Background: The apolipoprotein E (APOE, gene; apoE, protein) ε4 allele is the most commonly identified genetic risk factor for typical late-onset sporadic Alzheimer’s disease (AD). Each APOE ε4 allele roughly triples the ... -
Deciphering the Electronic Transitions of Thiophene-Based Donor-Acceptor-Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates.
Gustafsson, Camilla; Shirani, Hamid; Leira, Petter; Rhen, Dirk R.; Linares, Mathieu; Nilsson, K. Peter R.; Norman, Patrick; Lindgren, Mikael (Journal article; Peer reviewed, 2020)Anionic pentameric thiophene acetates can be used for fluorescence detection and diagnosis of protein amyloid aggregates. Replacing the central thiophene unit by benzothiadiazole (BTD) or quinoxaline (QX) leads to large ... -
Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation
Psonka-Antonczyk, Katarzyna Maria; Hammarström, Per; Johansson, Leif B. G.; Lindgren, Mikael; Stokke, Bjørn Torger; Nilsson, K. Peter R.; Nyström, Sofie (Peer reviewed; Journal article, 2016)Amyloid plaques composed of fibrillar Amyloid-β (Aβ) are hallmarks of Alzheimer's disease. However, Aβ fibrils are morphologically heterogeneous. Conformation sensitive luminescent conjugated oligothiophenes (LCOs) are ... -
Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States
Psonka-Antonczyk, Katarzyna Maria; Duboisset, Julien; Stokke, Bjørn Torger; Zako, Tamotsu; Kobayashi, Takahiro; Maeda, Mizuo; Nyström, Sofie; Mason, Jeffrey; Hammarström, Per; Nilsson, K. Peter R.; Lindgren, Mikael (Journal article; Peer reviewed, 2012)Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using ... -
Synthesis and characterization of novel fluoro-glycosylated porphyrins that can be utilized as theranostic agents
Arja, Katriann; Elgland, Mathias; Appelquist, Hanna; Konradsson, Peter; Lindgren, Mikael; Nilsson, K. Peter R. (Journal article; Peer reviewed, 2018)Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called ... -
Tau Protein Binding Modes in Alzheimer’s Disease for Cationic Luminescent Ligands
Todarwal, Yogesh; Gustafsson, Camilla; Thi Minh, Nghia Nguyen; Ertzgaard, Ingrid; Klingstedt, Thérese; Ghetti, Bernardino; Vidal, Ruben; König, Carolin; Lindgren, Mikael; Nilsson, K. Peter R.; Linares, Mathieu; Norman, Patrick (Journal article; Peer reviewed, 2021)The bi-thiophene-vinylene-benzothiazole (bTVBT4) ligand developed for Alzheimer’s disease (AD)-specific detection of amyloid tau has been studied by a combination of several theoretical methods and experimental spectroscopies. ... -
Tyrosine Side-Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes
Bäck, Marcus; Selegård, Robert; Todarwal, Yogesh; Nyström, Sofie; Norman, Patrick; Linares, Mathieu; Hammarström, Per; Lindgren, Mikael; Nilsson, K. Peter R. (Peer reviewed; Journal article, 2020)Control over the photophysical properties and molecular organization of π-conjugated oligothiophenes is essential to their use in organic electronics. Herein we synthesized and characterized a variety of anionic pentameric ...